Biodiversity loss and land degradation threaten climate resilience, food security, and ecological balance. The KSA Native Plant Genome Project (NPGP), led by the Research and Innovation Department at NCVC in collaboration with KAUST, exemplifies the power of genomic research in addressing these challenges. By integrating advanced technologies and interdisciplinary expertise, the NGP aligns with the Saudi Green Initiative (SGI), supports Vision 2030, and contributes to global frameworks like the UN Decade on Ecosystem Restoration.